Table of Contents

• Genetic modification of mesenchymal stem cells to enhance their anti-tumor efficacy

  Swathi Vangala, Gopikrishna Moku

  Non-hematopoietic mesenchymal stem cells (MSCs) are widely used in regenerative medicine and tissue engineering as they possess multilineage differentiation potential and self-renewal properties. MSCs can be easily isolated from several tissues and expanded following standard cell culture procedures. MSCs have the capability of mobilization to the tumor site; so, they can automatically relocate to...

  REVIEW | Published: 30 Mar 2021

  Annals of Urologic Oncology, Articles, Volume 2

  Pages: 1-6   PDF(484KB)

• Fabrication and bioactivity evaluation of curcumin and paclitaxel loaded lipid nanoparticles of pH-sensitive histidinylated cationic amphiphile

  Swathi Vangala, Gopikrishna Moku

  Drug resistance, inefficient cellular uptake and the subservient drug release to increase the intracellular drug concentration inside the tumor cells are the key reasons for low therapeutic efficacy of drug-loaded lipid nanoparticles in cancer therapy. Herein, we report on the design, synthesis and bioactivity evaluation of Curcumin & Paclitaxel (PTX) encapsulated endosomal pH-Sensitive lipid nano...

  RESEARCH | Published: 15 Apr 2021

  Annals of Urologic Oncology, Articles, Volume 2

  Pages: 7-16   PDF(3344KB)

• Are we ready to embrace novel therapeutic targets for women with AR-positive or AR-negative metastatic Triple-Negative Breast Cancer ?

  Katarzyna (Kate) Rygie

  Triple-negative breast cancer (TNBC) is characterized by the absence of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. Depending on the androgen receptor (AR) expression, TNBC can be further divided into AR-positive TNBC (a “classical TNBC subtype) and AR-negative TNBC that is synonymous with a quadruple-negative breast canc...

  REVIEW | Published: 06 Aug 2021

  Annals of Urologic Oncology, Articles, Volume 2

  Pages: 17-26   PDF(559KB)

• Effects of tumor microenvironment acidification on progression of pancreatic ductal adenocarcinoma: A review

  Manh Tien Tran

  Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and devastating disease, which is characterized by invasiveness, rapid progression and profound resistance to treatment. It has been best characterized that tumor microenvironment such as hypoxia and nutrient deprivation contributes to cancer progression; however, the role of tumor microenvironment acidification (TMA), a major feature of tum...

  REVIEW | Published: 05 Sep 2021

  Annals of Urologic Oncology, Articles, Volume 2

  Pages: 27-34   PDF(556KB)