All Articles

• RESEARCH  |  15 Apr 2021

  Fabrication and bioactivity evaluation of curcumin and paclitaxel loaded lipid nanoparticles of pH-sensitive histidinylated cationic amphiphile

  SWATHI VANGALA, GOPIKRISHNA MOKU. Drug resistance, inefficient cellular uptake and the subservient drug release to increase the intracellular drug concentration inside the tumor cells are the key reasons for low therapeutic efficacy of drug-loaded lipid nanoparticles in cancer therapy. Herein, we report on the design, synthesis and bioactivity evaluation of Curcumin & Paclitaxel (PTX) encapsulated...

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• REVIEW  |  15 Apr 2021

  Genetic modification of mesenchymal stem cells to enhance their anti-tumor efficacy

  SWATHI VANGALA, GOPIKRISHNA MOKU. Non-hematopoietic mesenchymal stem cells (MSCs) are widely used in regenerative medicine and tissue engineering as they possess multilineage differentiation potential and self-renewal properties. MSCs can be easily isolated from several tissues and expanded following standard cell culture procedures. MSCs have the capability of mobilization to the tumor site; so, ...

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• REVIEW  |  31 Dec 2020

  Navigating in the labyrinth of thrombotic and bleeding risks in patients with malignancies – how to make the most reasonable choices for personalized anticoagulation?

  KATARZYNA (KATE) RYGIEL. Venous thromboembolism (VTE) frequently occurs among patients with malignancies and poses an important cause of morbidity and mortality in this population. Therefore, effective and safe thromboprophylaxis for oncology patients at the increased risk of VTE is of utmost importance. Commonly used anticancer treatments, including hormonal therapy (HT), chemotherapy (CHT), targ...

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• RESEARCH  |  30 Dec 2020

  Implication of expression of MMR proteins and clinicopathological characteristics in gastric cancer

  RENU VERMA, PUJA SAKHUJA, RITU SRIVASTAVA, PRAKASH CHAND SHARMA. Introduction Microsatellite instability (MSI), referred to as variations at microsatellite loci, at mismatch repair (MMR) genes leads to the formation of an aberrant MMR system that fails to rectify errors occurring during DNA replication. MMR deficiency can be assessed by immunohistochemical analysis of the expression of mismatch re...

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• RESEARCH  |  19 Oct 2020

  Whole-exome sequencing reveals genetic underpinnings of tongue carcinoma in Chinese population

  SHUHANG WANG, NING JIANG, ZICHENG YU, YUAN FANG et al. Oral tongue squamous cell carcinoma (OTSCC) is a common malignancy, of which the incidence has increased in China in the last decade. Surprisingly, while multiple studies have revealed the mutational features of OTSCC in Western populations, limited data was shown in Asian patients. Herein, we utilized whole-exome sequencing to profile the gen...

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• RESEARCH  |  13 Oct 2020

  Temporal trends and geographic differences of insurance coverage for cancer drug trials in mainland China

  HUIYAO HUANG, YU TANG, QI FAN, DAWEIWU, et al. Background Data on insurance coverage of cancer drug trials in mainland China was of paucity, especially for its time trend and regional difference. Methods Based on the national authoritative database, time trend analysis of insurance coverage of cancer drug trials was conducted, from both the perspectives of trials and participants. Meanwhile, grou...

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