All Articles

• REVIEW  |  05 Sep 2021

  Effects of tumor microenvironment acidification on progression of pancreatic ductal adenocarcinoma: A review

  MANH TIEN TRAN. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and devastating disease, which is characterized by invasiveness, rapid progression and profound resistance to treatment. It has been best characterized that tumor microenvironment such as hypoxia and nutrient deprivation contributes to cancer progression; however, the role of tumor microenvironment acidification (TMA), a majo...

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• REVIEW  |  06 Aug 2021

  Are we ready to embrace novel therapeutic targets for women with AR-positive or AR-negative metastatic Triple-Negative Breast Cancer ?

  KATARZYNA (KATE) RYGIEL. Triple-negative breast cancer (TNBC) is characterized by the absence of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. Depending on the androgen receptor (AR) expression, TNBC can be further divided into AR-positive TNBC (a “classical TNBC subtype) and AR-negative TNBC that is synonymous with a quadr...

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• RESEARCH  |  15 Apr 2021

  Fabrication and bioactivity evaluation of curcumin and paclitaxel loaded lipid nanoparticles of pH-sensitive histidinylated cationic amphiphile

  SWATHI VANGALA, GOPIKRISHNA MOKU. Drug resistance, inefficient cellular uptake and the subservient drug release to increase the intracellular drug concentration inside the tumor cells are the key reasons for low therapeutic efficacy of drug-loaded lipid nanoparticles in cancer therapy. Herein, we report on the design, synthesis and bioactivity evaluation of Curcumin & Paclitaxel (PTX) encapsulated...

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• REVIEW  |  30 Mar 2021

  Genetic modification of mesenchymal stem cells to enhance their anti-tumor efficacy

  SWATHI VANGALA, GOPIKRISHNA MOKU. Non-hematopoietic mesenchymal stem cells (MSCs) are widely used in regenerative medicine and tissue engineering as they possess multilineage differentiation potential and self-renewal properties. MSCs can be easily isolated from several tissues and expanded following standard cell culture procedures. MSCs have the capability of mobilization to the tumor site; so, ...

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• REVIEW  |  31 Dec 2020

  Navigating in the labyrinth of thrombotic and bleeding risks in patients with malignancies – how to make the most reasonable choices for personalized anticoagulation?

  KATARZYNA (KATE) RYGIEL. Venous thromboembolism (VTE) frequently occurs among patients with malignancies and poses an important cause of morbidity and mortality in this population. Therefore, effective and safe thromboprophylaxis for oncology patients at the increased risk of VTE is of utmost importance. Commonly used anticancer treatments, including hormonal therapy (HT), chemotherapy (CHT), targ...

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• RESEARCH  |  30 Dec 2020

  Implication of expression of MMR proteins and clinicopathological characteristics in gastric cancer

  RENU VERMA, PUJA SAKHUJA, RITU SRIVASTAVA, PRAKASH CHAND SHARMA. Introduction Microsatellite instability (MSI), referred to as variations at microsatellite loci, at mismatch repair (MMR) genes leads to the formation of an aberrant MMR system that fails to rectify errors occurring during DNA replication. MMR deficiency can be assessed by immunohistochemical analysis of the expression of mismatch re...

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