Table of Contents

• Molecular mechanism of tumor microenvironment and recent approaches for the immunotherapy of pancreatic cancer

  Ayesha Fazal Nawaz, Muhammad Arif

  One of the most aggressive cancers, pancreatic cancer (PC) frequently has a dismal prognosis. The only known treatment for this illness is surgery, which is usually followed by adjuvant chemotherapy. However, only a tiny percentage of patients with resectable and non-metastatic tumors can receive surgery. In the future, more patients may be eligible for surgery thanks to customized neoadjuvant the...

  REVIEW | Published: 21 Dec 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 95-103   PDF(1590KB)   Views：6Downloads：1

• Current approaches to the management of neuroendocrine breast carcinoma (NEBC): a review

  Mohsen S. Ali

  Neuroendocrine breast carcinoma (NEBC), an infrequent malignancy, accounts for 2–5% of all invasive breast cancer cases. The minimal occurrence of these tumours has resulted in knowledge primarily acquired from unique case reports or short retrospective studies. NEBC is diagnosed by identifying morphological characteristics related to gastrointestinal tracts and lung neuroendocrine tumors and neur...

  REVIEW | Published: 27 Nov 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 85-94   PDF(2870KB)   Views：78Downloads：3

• Breast cancer stem cells origins and the memory stem cells: clinical significance of biomarkers and the active therapeutic approaches

  Muhammad Waseem Akram, Bai Chen

  Despite recent improvements in diagnosis and treatment, breast cancer (BC) remains one of the leading causes of cancer-related deaths among women. In this complex disease, breast cancer stem cells (BCSCs) are a small but significant subset of different cancer cells with the ability to proliferate and self-renew. According to an increasing amount of studies, BCSCs are essential for breast cancer me...

  REVIEW | Published: 08 Nov 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 76-84   PDF(1430KB)   Views：119Downloads：2

• The role of miRNAs as biomarkers in cancer

  Yifan Ou, Zhen Ren

  MicroRNAs (miRNAs), a class of non-coding RNAs, play a critical role in regulating gene expression and have demonstrated significant potential as biomarkers in cancer research. This review explores the role of miRNAs in tumorigenesis, invasion, and metastasis, highlighting their altered regulation in various cancers, including lung, breast, liver, colorectal, and prostate cancer. miRNA expression ...

  REVIEW | Published: 22 Oct 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 66-75   PDF(951KB)   Views：150Downloads：2

• Research advances in tumor diagnosis and early detection

  Rodney Bradly

  This review explores recent advances in tumor diagnosis and early detection, focusing on cutting-edge developments in molecular diagnostic technologies, imaging techniques, and the integration of multi-omics data. Current tumor diagnostic methods have limitations in terms of sensitivity and specificity, particularly for early tumor detection. However, with continuous progress in research and emerg...

  REVIEW | Published: 08 Oct 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 55-65   PDF(1050KB)   Views：176Downloads：1

• Research progress on the mechanisms, assessment methods, and intervention strategies for glioma-related cognitive impairment

  Riffat Iqbal, Zeeshan Ashraf

  Glioma-related cognitive dysfunction has emerged as a significant issue that affects the quality of life of patients. This paper aims to review the latest advancements in research on the mechanisms, assessment methods, and intervention strategies for glioma-induced cognitive impairment. First, it explored the potential mechanisms underlying glioma-related cognitive dysfunction, including the influ...

  REVIEW | Published: 11 Sep 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 46-54   PDF(1010KB)   Views：243Downloads：2

• Review of immunotherapy in non-small cell lung cancer: mechanisms, clinical applications, and future prospects

  Palwasha Habib

  Non-small cell lung cancer (NSCLC) ranks among the top contributors to cancer-related mortality globally. Recently, immunotherapy, particularly immune checkpoint inhibitors, has achieved groundbreaking progress in the treatment of NSCLC, significantly improving patient outcomes. This review explored the mechanisms of immunotherapy in NSCLC, with a focus on the roles of the PD-1/PD-L1 and CTLA-4 pa...

  REVIEW | Published: 11 Sep 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 39-45   PDF(1030KB)   Views：196Downloads：4

• Research on single-cell transcriptomics in hepatocellular carcinoma

  Nauman Shabbir

  Hepatocellular carcinoma (HCC) is the most prevalent malignant tumors of the digestive system globally, with a particularly high incidence recorded in China due to the prevalence of chronic hepatitis virus infections. Recent developments in single-cell RNA sequencing (scRNA-seq) technology have provided new perspectives and approaches for cancer research, particularly showing great potential in un...

  REVIEW | Published: 07 Sep 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 32-38   PDF(1050KB)   Views：187Downloads：0

• Mechanisms of gut microbiota dysbiosis and colorectal cancer risk: analysis and prospective interventions

  Dominic Kwesi Quainoo, Nadiya Habib

  This review comprehensively explores the mechanisms linking gut microbiota dysbiosis with the risk of colorectal cancer (CRC). Research indicates that gut microbiota imbalance may promote the occurrence and development of CRC through various pathways, including microbial metabolites, inflammatory responses, and alterations in the immune microenvironment. Specific mechanisms involve reducing short-...

  REVIEW | Published: 05 Sep 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 23-31   PDF(1310KB)   Views：211Downloads：9

• Development and advanced applications of hepatobiliary tumor organoid models in drug response prediction

  Changhua Zeng, Hongtan Lin ... Shen Chen

  Hepatobiliary tumors, including hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and gallbladder cancer, represent major causes of cancer-related mortality worldwide. Due to the lack of early symptoms, many patients are diagnosed at advanced stages, missing the optimal treatment window. Additionally, the elevated heterogeneity of hepatobiliary tumors and limited responsiveness to traditi...

  REVIEW | Published: 25 Aug 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 16-22   PDF(1859KB)   Views：234Downloads：2