REVIEW | 05 Sep 2021
Effects of tumor microenvironment acidification on progression of pancreatic ductal adenocarcinoma: A review
MANH TIEN TRAN. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and devastating disease, which is characterized by invasiveness, rapid progression and profound resistance to treatment. It has been best characterized that tumor microenvironment such as hypoxia and nutrient deprivation contributes to cancer progression; however, the role of tumor microenvironment acidification (TMA), a majo...