Table of Contents

• Research on single-cell transcriptomics in hepatocellular carcinoma

  Nauman Shabbir

  Hepatocellular carcinoma (HCC) is the most prevalent malignant tumors of the digestive system globally, with a particularly high incidence recorded in China due to the prevalence of chronic hepatitis virus infections. Recent developments in single-cell RNA sequencing (scRNA-seq) technology have provided new perspectives and approaches for cancer research, particularly showing great potential in un...

  REVIEW | Published: 07 Sep 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 32-38   PDF(1050KB)   Views：14Downloads：0

• Mechanisms of gut microbiota dysbiosis and colorectal cancer risk: analysis and prospective interventions

  Dominic Kwesi Quainoo, Nadiya Habib

  This review comprehensively explores the mechanisms linking gut microbiota dysbiosis with the risk of colorectal cancer (CRC). Research indicates that gut microbiota imbalance may promote the occurrence and development of CRC through various pathways, including microbial metabolites, inflammatory responses, and alterations in the immune microenvironment. Specific mechanisms involve reducing short-...

  REVIEW | Published: 05 Sep 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 23-31   PDF(1310KB)   Views：42Downloads：6

• Development and advanced applications of hepatobiliary tumor organoid models in drug response prediction

  Changhua Zeng, Hongtan Lin ... Shen Chen

  Hepatobiliary tumors, including hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and gallbladder cancer, represent major causes of cancer-related mortality worldwide. Due to the lack of early symptoms, many patients are diagnosed at advanced stages, missing the optimal treatment window. Additionally, the elevated heterogeneity of hepatobiliary tumors and limited responsiveness to traditi...

  REVIEW | Published: 25 Aug 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 16-22   PDF(1859KB)   Views：77Downloads：1

• Progress in research and treatment of immune checkpoints in breast cancer

  Xinyi Zhang, Jie Wang, Kaiyuan Zhou

  Breast cancer is the most common malignant tumor among women often involving the toxicity of conventional chemotherapy alongside organ-specific side effects. As immunotherapeutic agents in anti-tumor, new immune checkpoints are constantly being dug and discovered. The role of immune checkpoint inhibitors in the process of tumor immune evasion has assumed increasing significance. Currently, clinic...

  REVIEW | Published: 08 Apr 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 9-15   PDF(626KB)   Views：284Downloads：3

• Research progress of perioperative immunotherapy for locally advanced gastric cancer

  Shanbo Ma, Wei Zhang ... Hongbo Jiang

  Gastric cancer is a highly heterogeneous disease, and its occurrence and development are the result of genetic factors, environmental factors, and host factors. As one of the main types of cancer in China, radical gastrectomy is the only chance for patients to be cured, but only 50% to 60% of initially diagnosed gastric cancer patients are suitable for radical gastrectomy, especially in locally ad...

  REVIEW | Published: 08 Mar 2024

  Asia-Pacific Journal of Oncology, Articles, Online First

  Pages: 1-8   PDF(973KB)   Views：650Downloads：2

• Characteristics and outcomes of patients with small cell lung cancer - findings from a New Zealand SACT database

  Ross Lawrenson, Ha Nguyen ... Ian Kennedy

  Background Small Cell Lung Cancer (SCLC) SCLC generally presents late and is treated with systemic anti-cancer treatment (SACT). Māori are over represented in Lung Cancer statistics but disparities between Māori and non-Māori in patterns of care and survival from SCLC have not been previously reported. Methods We used the custom-built SACT database collected by the Oncology Department at Waikato ...

  RESEARCH | Published: 10 Feb 2023

  Asia-Pacific Journal of Oncology, Articles, Volume 4 (2023)

  Pages: 1-9   PDF(815KB)   Views：805Downloads：3

• Associations between KRAS status and clinical features in non-polyp colon cancer patients

  Cuong Hoang Minh, Huong Bui Thi Thu ... Thang Vu Hong

  Background Mutations of the KRAS gene are common in cancers; they are detected at a very high rate in colon cancer (CC) and are considered a negative disease factor. CC is among the deadliest cancers in Vietnam, and KRAS status for non-polyp colon cancer (NPCC) was rarely reported from the country. In this study, we aim to determine KRAS mutations and the associations of mutation status with clini...

  RESEARCH | Published: 29 Jun 2023

  Asia-Pacific Journal of Oncology, Articles, Volume 4 (2023)

  Pages: 10-16   PDF(1008KB)   Views：634Downloads：4

• A mini-review on metal-based breakthroughs in photodynamic therapy

  S. Dhinesh Kumar, Kaaviya. J

  This work aims to present Photodynamic Therapy (PDT) as an emerging approach for combating cancer, highlighting its effective therapeutic potential and distinctive attributes. Photodynamic therapy (PDT) stands as a groundbreaking approach in cancer treatment, rooted in Tappeiner’s revelation of oxygen-dependent photosensitizers’ impact on tumor cells under light. PDT operates by leveraging specifi...

  REVIEW | Published: 02 Dec 2023

  Asia-Pacific Journal of Oncology, Articles, Volume 4 (2023)

  Pages: 17-21   PDF(500KB)   Views：442Downloads：4

• An invitro evaluation of the cytotoxicity and p53-mediated apoptotic effect of ocimum sanctum leaves hexane extract on human oral cancer cell lines

  VR Naghul, Jerrine Joseph ... V. Ramesh Kumar

  Background Oral cancer is one of the most common cancers and the leading cause of cancer deaths worldwide. Florae have been inspiration of salutary sources for curing ailments since ages. Hence, the contemporary investigation was aimed at evaluating the anti-proliferative activity of extract of Ocimum sanctum leaves on oral cancer KB mouth cell line. Methods Extract preparation using soxhlet appa...

  RESEARCH | Published: 27 Dec 2022

  Asia-Pacific Journal of Oncology, Articles, Volume 3 (2022)

  Pages: 1-9   PDF(1680KB)   Views：821Downloads：1

• Adverse effects of the cancer therapy on osteoclast-mediated bone loss in patients with cancers: a challenge

  Manh Tien Tran

  It is well-known that cancer therapies, including chemotherapy drugs, aromatase inhibitors and gonadotropin-releasing homone analogues, commonly contribute to remarkably reduce the bone mineral density, subsequently increase the rate of bone loss. For instance, in the patients with prostate cancer treated with androgene deprivation therapy (ADT), or chemotherapy drugs such as doxorubicin and cispl...

  REVIEW | Published: 31 Dec 2022

  Asia-Pacific Journal of Oncology, Articles, Volume 3 (2022)

  Pages: 10-15   PDF(484KB)   Views：792Downloads：2