Table of Contents

• Associations between KRAS status and clinical features in non-polyp colon cancer patients

  Cuong Hoang Minh, Huong Bui Thi Thu ... Thang Vu Hong

  Background Mutations of the KRAS gene are common in cancers; they are detected at a very high rate in colon cancer (CC) and are considered a negative disease factor. CC is among the deadliest cancers in Vietnam, and KRAS status for non-polyp colon cancer (NPCC) was rarely reported from the country. In this study, we aim to determine KRAS mutations and the associations of mutation status with clini...

  RESEARCH | Published: 29 Jun 2023

  Asia-Pacific Journal of Oncology, Articles, Volume 4 (2023)

  Pages: 10-16   PDF(1008KB)   Views：961Downloads：7

• Characteristics and outcomes of patients with small cell lung cancer - findings from a New Zealand SACT database

  Ross Lawrenson, Ha Nguyen ... Ian Kennedy

  Background Small Cell Lung Cancer (SCLC) SCLC generally presents late and is treated with systemic anti-cancer treatment (SACT). Māori are over represented in Lung Cancer statistics but disparities between Māori and non-Māori in patterns of care and survival from SCLC have not been previously reported. Methods We used the custom-built SACT database collected by the Oncology Department at Waikato ...

  RESEARCH | Published: 10 Feb 2023

  Asia-Pacific Journal of Oncology, Articles, Volume 4 (2023)

  Pages: 1-9   PDF(815KB)   Views：1057Downloads：5

• Nanogold: a versatile therapeutic agent in oncology

  Mater H. Mahnashia, Bander A. Alyami ... Arif Ullah Khan

  Nanogold is an emerging and versatile therapeutic agent since decades. Nanoogold and its’complexes can be synthesized through different ways. Its’ use in oncology as a drug delivery vehicle, phothothermal agent, Nucliec acid delivery vehicle and a photodynamic agent has been investigated by many researchers. Au nanoparticles (AuNPs) are nanovehicles with inimitable optical properties and incredibl...

  REVIEW | Published: 31 Dec 2022

  Asia-Pacific Journal of Oncology, Articles, Volume 3 (2022)

  Pages: 16-21   PDF(630KB)   Views：931Downloads：2

• Adverse effects of the cancer therapy on osteoclast-mediated bone loss in patients with cancers: a challenge

  Manh Tien Tran

  It is well-known that cancer therapies, including chemotherapy drugs, aromatase inhibitors and gonadotropin-releasing homone analogues, commonly contribute to remarkably reduce the bone mineral density, subsequently increase the rate of bone loss. For instance, in the patients with prostate cancer treated with androgene deprivation therapy (ADT), or chemotherapy drugs such as doxorubicin and cispl...

  REVIEW | Published: 31 Dec 2022

  Asia-Pacific Journal of Oncology, Articles, Volume 3 (2022)

  Pages: 10-15   PDF(484KB)   Views：1093Downloads：2

• An invitro evaluation of the cytotoxicity and p53-mediated apoptotic effect of ocimum sanctum leaves hexane extract on human oral cancer cell lines

  VR Naghul, Jerrine Joseph ... V. Ramesh Kumar

  Background Oral cancer is one of the most common cancers and the leading cause of cancer deaths worldwide. Florae have been inspiration of salutary sources for curing ailments since ages. Hence, the contemporary investigation was aimed at evaluating the anti-proliferative activity of extract of Ocimum sanctum leaves on oral cancer KB mouth cell line. Methods Extract preparation using soxhlet appa...

  RESEARCH | Published: 27 Dec 2022

  Asia-Pacific Journal of Oncology, Articles, Volume 3 (2022)

  Pages: 1-9   PDF(1680KB)   Views：1084Downloads：1

• Effects of tumor microenvironment acidification on progression of pancreatic ductal adenocarcinoma: A review

  Manh Tien Tran

  Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and devastating disease, which is characterized by invasiveness, rapid progression and profound resistance to treatment. It has been best characterized that tumor microenvironment such as hypoxia and nutrient deprivation contributes to cancer progression; however, the role of tumor microenvironment acidification (TMA), a major feature of tum...

  REVIEW | Published: 05 Sep 2021

  Asia-Pacific Journal of Oncology, Articles, Volume 2 (2021)

  Pages: 27-34   PDF(556KB)   Views：1540Downloads：6

• Are we ready to embrace novel therapeutic targets for women with AR-positive or AR-negative metastatic Triple-Negative Breast Cancer ?

  Katarzyna (Kate) Rygie

  Triple-negative breast cancer (TNBC) is characterized by the absence of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. Depending on the androgen receptor (AR) expression, TNBC can be further divided into AR-positive TNBC (a “classical TNBC subtype) and AR-negative TNBC that is synonymous with a quadruple-negative breast canc...

  REVIEW | Published: 06 Aug 2021

  Asia-Pacific Journal of Oncology, Articles, Volume 2 (2021)

  Pages: 17-26   PDF(559KB)   Views：1198Downloads：4

• Fabrication and bioactivity evaluation of curcumin and paclitaxel loaded lipid nanoparticles of pH-sensitive histidinylated cationic amphiphile

  Swathi Vangala, Gopikrishna Moku

  Drug resistance, inefficient cellular uptake and the subservient drug release to increase the intracellular drug concentration inside the tumor cells are the key reasons for low therapeutic efficacy of drug-loaded lipid nanoparticles in cancer therapy. Herein, we report on the design, synthesis and bioactivity evaluation of Curcumin & Paclitaxel (PTX) encapsulated endosomal pH-Sensitive lipid nano...

  RESEARCH | Published: 15 Apr 2021

  Asia-Pacific Journal of Oncology, Articles, Volume 2 (2021)

  Pages: 7-16   PDF(3344KB)   Views：1683Downloads：5

• Genetic modification of mesenchymal stem cells to enhance their anti-tumor efficacy

  Swathi Vangala, Gopikrishna Moku

  Non-hematopoietic mesenchymal stem cells (MSCs) are widely used in regenerative medicine and tissue engineering as they possess multilineage differentiation potential and self-renewal properties. MSCs can be easily isolated from several tissues and expanded following standard cell culture procedures. MSCs have the capability of mobilization to the tumor site; so, they can automatically relocate to...

  REVIEW | Published: 30 Mar 2021

  Asia-Pacific Journal of Oncology, Articles, Volume 2 (2021)

  Pages: 1-6   PDF(484KB)   Views：1769Downloads：5

• Navigating in the labyrinth of thrombotic and bleeding risks in patients with malignancies – how to make the most reasonable choices for personalized anticoagulation?

  Katarzyna (Kate) Rygiel

  Venous thromboembolism (VTE) frequently occurs among patients with malignancies and poses an important cause of morbidity and mortality in this population. Therefore, effective and safe thromboprophylaxis for oncology patients at the increased risk of VTE is of utmost importance. Commonly used anticancer treatments, including hormonal therapy (HT), chemotherapy (CHT), targeted therapy (TT), immune...

  REVIEW | Published: 31 Dec 2020

  Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

  Pages: 68-76   PDF(1280KB)   Views：1356Downloads：3