Table of Contents

• Fabrication and bioactivity evaluation of curcumin and paclitaxel loaded lipid nanoparticles of pH-sensitive histidinylated cationic amphiphile

  Swathi Vangala, Gopikrishna Moku

  Drug resistance, inefficient cellular uptake and the subservient drug release to increase the intracellular drug concentration inside the tumor cells are the key reasons for low therapeutic efficacy of drug-loaded lipid nanoparticles in cancer therapy. Herein, we report on the design, synthesis and bioactivity evaluation of Curcumin & Paclitaxel (PTX) encapsulated endosomal pH-Sensitive lipid nano...

  RESEARCH | Published: 15 Apr 2021

  Asia-Pacific Journal of Oncology, Articles, Volume 2 (2021)

  Pages: 7-16   PDF(3344KB)   Views：1569Downloads：5

• Genetic modification of mesenchymal stem cells to enhance their anti-tumor efficacy

  Swathi Vangala, Gopikrishna Moku

  Non-hematopoietic mesenchymal stem cells (MSCs) are widely used in regenerative medicine and tissue engineering as they possess multilineage differentiation potential and self-renewal properties. MSCs can be easily isolated from several tissues and expanded following standard cell culture procedures. MSCs have the capability of mobilization to the tumor site; so, they can automatically relocate to...

  REVIEW | Published: 30 Mar 2021

  Asia-Pacific Journal of Oncology, Articles, Volume 2 (2021)

  Pages: 1-6   PDF(484KB)   Views：1629Downloads：4

• Navigating in the labyrinth of thrombotic and bleeding risks in patients with malignancies – how to make the most reasonable choices for personalized anticoagulation?

  Katarzyna (Kate) Rygiel

  Venous thromboembolism (VTE) frequently occurs among patients with malignancies and poses an important cause of morbidity and mortality in this population. Therefore, effective and safe thromboprophylaxis for oncology patients at the increased risk of VTE is of utmost importance. Commonly used anticancer treatments, including hormonal therapy (HT), chemotherapy (CHT), targeted therapy (TT), immune...

  REVIEW | Published: 31 Dec 2020

  Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

  Pages: 68-76   PDF(1280KB)   Views：1220Downloads：3

• Implication of expression of MMR proteins and clinicopathological characteristics in gastric cancer

  Renu Verma, Puja Sakhuja ... Prakash Chand Sharma

  Microsatellite instability (MSI), referred to as variations at microsatellite loci, at mismatch repair (MMR) genes leads to the formation of an aberrant MMR system that fails to rectify errors occurring during DNA replication. MMR deficiency can be assessed by immunohistochemical analysis of the expression of mismatch repair proteins in the target tissues. Our results implicate the role of mismat...

  RESEARCH | Published: 30 Dec 2020

  Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

  Pages: 61-67   PDF(4210KB)   Views：1603Downloads：4

• Whole-exome sequencing reveals genetic underpinnings of tongue carcinoma in Chinese population

  Shuhang Wang, Ning Jiang .. Ning Li

  Oral tongue squamous cell carcinoma (OTSCC) is a common malignancy, of which the incidence has increased in China in the last decade. Surprisingly, while multiple studies have revealed the mutational features of OTSCC in Western populations, limited data was shown in Asian patients. Herein, we utilized whole-exome sequencing to profile the genetic alterations in 13 Chinese OTSCC and compared them ...

  RESEARCH | Published: 19 Oct 2020

  Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

  Pages: 52-60   PDF(1920KB)   Views：3473Downloads：2

• Temporal trends and geographic differences of insurance coverage for cancer drug trials in mainland China

  Huiyao Huang, Yu Tang ... Ning Li

  The insurance coverage of cancer drug trials in mainland China has been increasing steadily over the past decade. However, the regional differences are significant. To promote insurance coverage emphatically in underdeveloped areas could be our work emphasis. Although this study specially included cancer drug trials, the results could also provide reference for trials in all other fields....

  RESEARCH | Published: 13 Oct 2020

  Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

  Pages: 45-51   PDF(1210KB)   Views：3577Downloads：2

• Labeling of ethylenediamine tetramethylene phosphonate with 153Sm and 177Lu, comparison study

  Hesham MH Zakaly, Mostafa Y. A. Mostafa, M Zhukovsky

  Background 177Lu and 153Sm are perspective radionuclides in terms of applying to nuclear medicine. High-energy beta particles and the relative half-life of the radionuclide are used to achieve an effective palliative treatment of bone metastases. Materials and methods The absorbed doses in different organs and tissues of 177Lu and 153Sm ...

  RESEARCH | Published: 03 Oct 2020

  Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

  Pages: 38-44   PDF(1530KB)   Views：1290Downloads：4

• A multi-center, signal-arm study on cancer patients’ perception of chemotherapy side effects, depression, and decision regret at the end of adjuvant treatment

  Caterina Calderon, Raquel Hernández ... Paula Jiménez-Fonseca

  Purpose The aim was to assess patients’ perception of chemotherapy side effects and analyze the relationship between these, depression, and treatment rejection. Methods A multi-center, signal-arm study in 456 patients with resected, non-metastatic cancer. Conducted upon completion of adjuvant chemotherapy. Participants answered questionnair...

  RESEARCH | Published: 23 Sep 2020

  Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

  Pages: 31-37   PDF(609KB)   Views：1607Downloads：3

• Niclosamide exerts anti-tumor activity through generation of reactive oxygen species and by suppression of Wnt/ β-catenin signaling axis in HGC-27, MKN-74 human gastric cancer cells

  Manish Kumar Jeengar, Shravan Kumar ... V.G.M. Naidu

  Introduction Gastric carcinoma (GC) remains a therapeutic challenge despite having many potent drugs to treat. Various studies emphasized the role of dysregulated Wnt/β-catenin pathway in cancer. In the present study, we examined the anti-cancer effect of Niclosamide and its effect on the dysregulated β-catenin pathway in human gastri...

  RESEARCH | Published: 12 Aug 2020

  Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

  Pages: 18-30   PDF(3940KB)   Views：2081Downloads：4

• Clinical impact of oncomirs 221 and 222 on breast cancer diagnosis

  Elham Ali Ahmed, Sohair A. Abd El-bast ... Menha Swellam

  Dysregulation of miRNAs, non-coding RNAs of 18-25 ( ̴ 22nt), is a hallmark of malignancies among them is breast cancer. The present study aimed to investigate the expression levels of circulating oncomiRNAs (miRNA-221and miRNA-222) as a minimally non-invasive method for early detection of breast cancer as compared to tumor markers (CEA, CA15.3). MiRNA-221 and miRNA-222 were superior over tumor ma...

  RESEARCH | Published: 26 Jul 2020

  Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

  Pages: 9-17   PDF(666KB)   Views：1742Downloads：5