Table of Contents

• Adverse effects of the cancer therapy on osteoclast-mediated bone loss in patients with cancers: a challenge

  Manh Tien Tran

  It is well-known that cancer therapies, including chemotherapy drugs, aromatase inhibitors and gonadotropin-releasing homone analogues, commonly contribute to remarkably reduce the bone mineral density, subsequently increase the rate of bone loss. For instance, in the patients with prostate cancer treated with androgene deprivation therapy (ADT), or chemotherapy drugs such as doxorubicin and cispl...

  REVIEW | Published: 31 Dec 2022

  Asia-Pacific Journal of Oncology, Articles, Volume 3 (2022)

  Pages: 10-15   PDF(484KB)   Views：984Downloads：2

• An invitro evaluation of the cytotoxicity and p53-mediated apoptotic effect of ocimum sanctum leaves hexane extract on human oral cancer cell lines

  VR Naghul, Jerrine Joseph ... V. Ramesh Kumar

  Background Oral cancer is one of the most common cancers and the leading cause of cancer deaths worldwide. Florae have been inspiration of salutary sources for curing ailments since ages. Hence, the contemporary investigation was aimed at evaluating the anti-proliferative activity of extract of Ocimum sanctum leaves on oral cancer KB mouth cell line. Methods Extract preparation using soxhlet appa...

  RESEARCH | Published: 27 Dec 2022

  Asia-Pacific Journal of Oncology, Articles, Volume 3 (2022)

  Pages: 1-9   PDF(1680KB)   Views：987Downloads：1

• Effects of tumor microenvironment acidification on progression of pancreatic ductal adenocarcinoma: A review

  Manh Tien Tran

  Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and devastating disease, which is characterized by invasiveness, rapid progression and profound resistance to treatment. It has been best characterized that tumor microenvironment such as hypoxia and nutrient deprivation contributes to cancer progression; however, the role of tumor microenvironment acidification (TMA), a major feature of tum...

  REVIEW | Published: 05 Sep 2021

  Asia-Pacific Journal of Oncology, Articles, Volume 2 (2021)

  Pages: 27-34   PDF(556KB)   Views：1436Downloads：5

• Are we ready to embrace novel therapeutic targets for women with AR-positive or AR-negative metastatic Triple-Negative Breast Cancer ?

  Katarzyna (Kate) Rygie

  Triple-negative breast cancer (TNBC) is characterized by the absence of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. Depending on the androgen receptor (AR) expression, TNBC can be further divided into AR-positive TNBC (a “classical TNBC subtype) and AR-negative TNBC that is synonymous with a quadruple-negative breast canc...

  REVIEW | Published: 06 Aug 2021

  Asia-Pacific Journal of Oncology, Articles, Volume 2 (2021)

  Pages: 17-26   PDF(559KB)   Views：1115Downloads：4

• Fabrication and bioactivity evaluation of curcumin and paclitaxel loaded lipid nanoparticles of pH-sensitive histidinylated cationic amphiphile

  Swathi Vangala, Gopikrishna Moku

  Drug resistance, inefficient cellular uptake and the subservient drug release to increase the intracellular drug concentration inside the tumor cells are the key reasons for low therapeutic efficacy of drug-loaded lipid nanoparticles in cancer therapy. Herein, we report on the design, synthesis and bioactivity evaluation of Curcumin & Paclitaxel (PTX) encapsulated endosomal pH-Sensitive lipid nano...

  RESEARCH | Published: 15 Apr 2021

  Asia-Pacific Journal of Oncology, Articles, Volume 2 (2021)

  Pages: 7-16   PDF(3344KB)   Views：1600Downloads：5

• Genetic modification of mesenchymal stem cells to enhance their anti-tumor efficacy

  Swathi Vangala, Gopikrishna Moku

  Non-hematopoietic mesenchymal stem cells (MSCs) are widely used in regenerative medicine and tissue engineering as they possess multilineage differentiation potential and self-renewal properties. MSCs can be easily isolated from several tissues and expanded following standard cell culture procedures. MSCs have the capability of mobilization to the tumor site; so, they can automatically relocate to...

  REVIEW | Published: 30 Mar 2021

  Asia-Pacific Journal of Oncology, Articles, Volume 2 (2021)

  Pages: 1-6   PDF(484KB)   Views：1675Downloads：5

• Navigating in the labyrinth of thrombotic and bleeding risks in patients with malignancies – how to make the most reasonable choices for personalized anticoagulation?

  Katarzyna (Kate) Rygiel

  Venous thromboembolism (VTE) frequently occurs among patients with malignancies and poses an important cause of morbidity and mortality in this population. Therefore, effective and safe thromboprophylaxis for oncology patients at the increased risk of VTE is of utmost importance. Commonly used anticancer treatments, including hormonal therapy (HT), chemotherapy (CHT), targeted therapy (TT), immune...

  REVIEW | Published: 31 Dec 2020

  Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

  Pages: 68-76   PDF(1280KB)   Views：1264Downloads：3

• Implication of expression of MMR proteins and clinicopathological characteristics in gastric cancer

  Renu Verma, Puja Sakhuja ... Prakash Chand Sharma

  Microsatellite instability (MSI), referred to as variations at microsatellite loci, at mismatch repair (MMR) genes leads to the formation of an aberrant MMR system that fails to rectify errors occurring during DNA replication. MMR deficiency can be assessed by immunohistochemical analysis of the expression of mismatch repair proteins in the target tissues. Our results implicate the role of mismat...

  RESEARCH | Published: 30 Dec 2020

  Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

  Pages: 61-67   PDF(4210KB)   Views：1641Downloads：4

• Whole-exome sequencing reveals genetic underpinnings of tongue carcinoma in Chinese population

  Shuhang Wang, Ning Jiang .. Ning Li

  Oral tongue squamous cell carcinoma (OTSCC) is a common malignancy, of which the incidence has increased in China in the last decade. Surprisingly, while multiple studies have revealed the mutational features of OTSCC in Western populations, limited data was shown in Asian patients. Herein, we utilized whole-exome sequencing to profile the genetic alterations in 13 Chinese OTSCC and compared them ...

  RESEARCH | Published: 19 Oct 2020

  Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

  Pages: 52-60   PDF(1920KB)   Views：3513Downloads：2

• Temporal trends and geographic differences of insurance coverage for cancer drug trials in mainland China

  Huiyao Huang, Yu Tang ... Ning Li

  The insurance coverage of cancer drug trials in mainland China has been increasing steadily over the past decade. However, the regional differences are significant. To promote insurance coverage emphatically in underdeveloped areas could be our work emphasis. Although this study specially included cancer drug trials, the results could also provide reference for trials in all other fields....

  RESEARCH | Published: 13 Oct 2020

  Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

  Pages: 45-51   PDF(1210KB)   Views：3634Downloads：2