Table of Contents

• Ubiquitin-specific proteases as emerging molecular drivers and therapeutic targets in hepatobiliary cancers

  Enas Roumieh, Waqas Bin Ismail, Samahir Sheikh Idris

  Hepatobiliary malignancies, such as gallbladder carcinoma (GBC), cholangiocarcinoma (CCA), and hepatocellular carcinoma (HCC), continue to be extremely deadly because of their late diagnosis, intertumoral heterogeneity, recurrence, and resistance to treatment. Finding new molecular drivers is crucial to enhancing diagnosis and therapy. Hepatobiliary tumor biology is significantly regulated by the ...

  REVIEW | Published: 31 Oct 2025

  Asia-Pacific Journal of Oncology, Articles, Volume 6 (2025)

  Pages: 55-69   PDF(3633KB)   Views：216Downloads：6

• Applications and future prospects of artificial intelligence in the diagnosis and prognosis of lung cancer

  Soha Kareem

  With its annual incidence gradually rising and hence a major threat to public health, lung carcinoma is a major contributor to cancer-associated death worldwide. Artificial intelligence (AI) in computer science refers to research on robots, language processing, image recognition, speech, and machine learning (ML) applications. This will change the physician’s approach to cancer management. Given i...

  REVIEW | Published: 15 Sep 2025

  Asia-Pacific Journal of Oncology, Articles, Volume 6 (2025)

  Pages: 47-54   PDF(1710KB)   Views：387Downloads：6

• Potential mechanisms of intestinal microbes in bone metastasis of breast cancer

  Nicky Gile, Luke Johnston

  Breast cancer (BRCA) is the most common type of cancer in women worldwide, with distant metastases most frequently occurring in the skeleton. Bone metastasis in BRCA often leads to severe bone pain, pathological fractures, spinal cord compression, and other complications, significantly reducing the patients' quality of life. Recently, the role of intestinal microbes in BRCA bone metastasis has gai...

  REVIEW | Published: 31 Mar 2025

  Asia-Pacific Journal of Oncology, Articles, Volume 6 (2025)

  Pages: 37-46   PDF(2290KB)   Views：700Downloads：4

• Deubiquitinases as novel therapeutic targets in colorectal cancer

  Noor Al Shukri, Razik Bin Abdul Momin

  Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality and is the third most prevalent malignant tumor in the world. In recent years, the key role of protein post-translational modifications, especially ubiquitination and deubiquitination modifications, in tumorigenesis and progression has gradually been revealed. Deuubiquitinating Enzymes (DUBs) play an important role in...

  REVIEW | Published: 17 Mar 2025

  Asia-Pacific Journal of Oncology, Articles, Volume 6 (2025)

  Pages: 27-36   PDF(1563KB)   Views：808Downloads：5

• Innovative and future approaches for ovarian cancer detection and evaluation: a comprehensive review

  Fomukong Tasinda Raphael, Simon Nabirye

  Gynecological malignancies, characterized by their aggressive nature and tendency to recur, are associated with poorer outcomes and suboptimal responses to available treatment modalities. Ovarian cancer (OC) is frequently present at advanced stages, wherein therapeutic resistance, angiogenesis, recurrence, and metastatic spread significantly affect patient survival rates. The primary therapeutic a...

  REVIEW | Published: 04 Feb 2025

  Asia-Pacific Journal of Oncology, Articles, Volume 6 (2025)

  Pages: 18-26   PDF(1370KB)   Views：995Downloads：4

• Liquid biopsy: an emerging field with new opportunities for cancer diagnosis and prognosis

  Dhahiri Saidi Mashausi, Semukunzi Herve

  Cancer grades among the deadliest diseases, globally causing the death of a over million people each year. Early diagnosis has been considered ideal for efficient treatment as during later stages chances of treatment become limited. However, gold standard tissue biopsy has various limitation for instance, late-stage diagnosis and its intrusive operation making it unfit for repeated sampling. Scien...

  REVIEW | Published: 14 Jan 2025

  Asia-Pacific Journal of Oncology, Articles, Volume 6 (2025)

  Pages: 9-17   PDF(1990KB)   Views：981Downloads：16

• Current perspectives on glioblastoma treatment synergies between therapies and delivery systems

  Debanjan Das

  In adults, glioblastoma multiforme (GBM) is considered the most widespread and virulent malignancy of the central nervous system (CNS). This formidable brain tumor stands out as one of the most lethal types within the CNS cancer classification. Despite ongoing advancements in modality therapy, a curative solution remains largely unattainable. Consequently, the imperative to develop innovative syst...

  REVIEW | Published: 05 Jan 2025

  Asia-Pacific Journal of Oncology, Articles, Volume 6 (2025)

  Pages: 1-8   PDF(1050KB)   Views：1166Downloads：9

• Cellular senescence and tumor dormancy at the crossroads of therapy resistance, metastasis and cancer stemness

  Qurrat Ul Ain

  Senescence is irreversible cell cycle arrest that results from therapy-induced stress such as DNA damage. It was initially thought to be a tumor-suppressive mechanism, but now getting attention to contribute to tumor progression and therapy resistance through the senescence-associated secretory phenotype (SASP). Remodeling the tumor microenvironment (TME), SASP can establish conditions conducive t...

  REVIEW | Published: 29 Dec 2024

  Asia-Pacific Journal of Oncology, Articles, Volume 5 (2024)

  Pages: 112-120   PDF(1490KB)   Views：1171Downloads：13

• Next frontier in cancer treatment: an iPSC supported CAR-T cell therapies

  Tayyaba Sona

  The spread of cancer and huge number of cancer related deaths has made it imperative for scientist to search new diagnostic, prognostic and treatment tools for its effective management. Chimeric Antigen Receptor (CAR) T-cell (CAR-T) therapy has been brought into limelight as novel treatment strategy for cancer. In this review we briefly introduced the CAR-T therapy highlighting its successful app...

  REVIEW | Published: 27 Dec 2024

  Asia-Pacific Journal of Oncology, Articles, Volume 5 (2024)

  Pages: 104-111   PDF(1890KB)   Views：957Downloads：3

• Molecular mechanism of tumor microenvironment and recent approaches for the immunotherapy of pancreatic cancer

  Ayesha Fazal Nawaz, Muhammad Arif

  One of the most aggressive cancers, pancreatic cancer (PC) frequently has a dismal prognosis. The only known treatment for this illness is surgery, which is usually followed by adjuvant chemotherapy. However, only a tiny percentage of patients with resectable and non-metastatic tumors can receive surgery. In the future, more patients may be eligible for surgery thanks to customized neoadjuvant the...

  REVIEW | Published: 21 Dec 2024

  Asia-Pacific Journal of Oncology, Articles, Volume 5 (2024)

  Pages: 95-103   PDF(1590KB)   Views：935Downloads：9