All Articles

• RESEARCH  |  19 Oct 2020

  Whole-exome sequencing reveals genetic underpinnings of tongue carcinoma in Chinese population

  SHUHANG WANG, NING JIANG, ZICHENG YU, YUAN FANG et al. Oral tongue squamous cell carcinoma (OTSCC) is a common malignancy, of which the incidence has increased in China in the last decade. Surprisingly, while multiple studies have revealed the mutational features of OTSCC in Western populations, limited data was shown in Asian patients. Herein, we utilized whole-exome sequencing to profile the gen...

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• RESEARCH  |  13 Oct 2020

  Temporal trends and geographic differences of insurance coverage for cancer drug trials in mainland China

  HUIYAO HUANG, YU TANG, QI FAN, DAWEIWU, et al. Background Data on insurance coverage of cancer drug trials in mainland China was of paucity, especially for its time trend and regional difference. Methods Based on the national authoritative database, time trend analysis of insurance coverage of cancer drug trials was conducted, from both the perspectives of trials and participants. Meanwhile, grou...

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• RESEARCH  |  03 Oct 2020

  Labeling of ethylenediamine tetramethylene phosphonate with 153Sm and 177Lu, comparison study

  HESHAM MH ZAKALY, MOSTAFA Y. A. MPSTAFA, M ZHUKOVSKY et al. Background 177Lu and 153Sm are perspective radionuclides in terms of applying to nuclear medicine. High-energy beta particles and the relative half-life of the radionuclide are used to achieve an effective palliative treatment of bone metastases. Materials and methods The absorbed doses in different organs and tissues of 177Lu and 153Sm ...

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• RESEARCH  |  23 Sep 2020

  A multi-center, signal-arm study on cancer patients’ perception of chemotherapy side effects, depression, and decision regret at the end of adjuvant treatment

  CATERINA CALDERON, RAQUEL HERNANDEZ, DAVID GOMEZ et al. Purpose The aim was to assess patients’ perception of chemotherapy side effects and analyze the relationship between these, depression, and treatment rejection. Methods A multi-center, signal-arm study in 456 patients with resected, non-metastatic cancer. Conducted upon completion of adjuvant chemotherapy. Participants answered questionnair...

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• RESEARCH  |  12 Aug 2020

  Niclosamide exerts anti-tumor activity through generation of reactive oxygen species and by suppression of Wnt/ β-catenin signaling axis in HGC-27, MKN-74 human gastric cancer cells

  MANISH KUMAR JEENGAR, SHRAVAN KUMAR, SHWETA SHRIVASTAVA, et al. Introduction Gastric carcinoma (GC) remains a therapeutic challenge despite having many potent drugs to treat. Various studies emphasized the role of dysregulated Wnt/β-catenin pathway in cancer. In the present study, we examined the anti-cancer effect of Niclosamide and its effect on the dysregulated β-catenin pathway in human gastri...

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• RESEARCH  |  26 Jul 2020

  Clinical impact of oncomirs 221 and 222 on breast cancer diagnosis

  EIHAM ALI AHMED, SOHAIR A. ABD EI-BLAST, MONA A. MOHAMED, MENHA SWELLAM. Background Dysregulation of miRNAs, non-coding RNAs of 18-25 ( ̴ 22nt), is a hallmark of malignancies among them is breast cancer. The present study aimed to investigate the expression levels of circulating oncomiRNAs (miRNA-221and miRNA-222) as a minimally non-invasive method for early detection of breast cancer as compared...

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