Personomics – an innovative tool of precision medicine and its role in the individualized treatment of patients with breast cancer

Katarzyna Rygiel

Precision medicine considers specific biological characteristics of each individual patient to tailor diagnostic and therapeutic strategies to a given patient. This approach is particularly important for a growing number of patients with malignancies. Currently, some unique biological properties in the terms of different “omics” platforms (e.g., genomics, proteomics, transcriptomics, metabolomics,...
REVIEW | Published: 23 Jul 2020

Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

Pages: 1-8 PDF(757KB) Views：1685Downloads：5
Clinical impact of oncomirs 221 and 222 on breast cancer diagnosis

Elham Ali Ahmed, Sohair A. Abd El-bast ... Menha Swellam

Dysregulation of miRNAs, non-coding RNAs of 18-25 ( ̴ 22nt), is a hallmark of malignancies among them is breast cancer. The present study aimed to investigate the expression levels of circulating oncomiRNAs (miRNA-221and miRNA-222) as a minimally non-invasive method for early detection of breast cancer as compared to tumor markers (CEA, CA15.3). MiRNA-221 and miRNA-222 were superior over tumor ma...
RESEARCH | Published: 26 Jul 2020

Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

Pages: 9-17 PDF(666KB) Views：1742Downloads：5
Niclosamide exerts anti-tumor activity through generation of reactive oxygen species and by suppression of Wnt/ β-catenin signaling axis in HGC-27, MKN-74 human gastric cancer cells

Manish Kumar Jeengar, Shravan Kumar ... V.G.M. Naidu

Introduction Gastric carcinoma (GC) remains a therapeutic challenge despite having many potent drugs to treat. Various studies emphasized the role of dysregulated Wnt/β-catenin pathway in cancer. In the present study, we examined the anti-cancer effect of Niclosamide and its effect on the dysregulated β-catenin pathway in human gastri...
RESEARCH | Published: 12 Aug 2020

Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

Pages: 18-30 PDF(3940KB) Views：2081Downloads：4
A multi-center, signal-arm study on cancer patients’ perception of chemotherapy side effects, depression, and decision regret at the end of adjuvant treatment

Caterina Calderon, Raquel Hernández ... Paula Jiménez-Fonseca

Purpose The aim was to assess patients’ perception of chemotherapy side effects and analyze the relationship between these, depression, and treatment rejection. Methods A multi-center, signal-arm study in 456 patients with resected, non-metastatic cancer. Conducted upon completion of adjuvant chemotherapy. Participants answered questionnair...
RESEARCH | Published: 23 Sep 2020

Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

Pages: 31-37 PDF(609KB) Views：1607Downloads：3
Labeling of ethylenediamine tetramethylene phosphonate with 153Sm and 177Lu, comparison study

Hesham MH Zakaly, Mostafa Y. A. Mostafa, M Zhukovsky

Background 177Lu and 153Sm are perspective radionuclides in terms of applying to nuclear medicine. High-energy beta particles and the relative half-life of the radionuclide are used to achieve an effective palliative treatment of bone metastases. Materials and methods The absorbed doses in different organs and tissues of 177Lu and 153Sm ...
RESEARCH | Published: 03 Oct 2020

Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

Pages: 38-44 PDF(1530KB) Views：1290Downloads：4
Temporal trends and geographic differences of insurance coverage for cancer drug trials in mainland China

Huiyao Huang, Yu Tang ... Ning Li

The insurance coverage of cancer drug trials in mainland China has been increasing steadily over the past decade. However, the regional differences are significant. To promote insurance coverage emphatically in underdeveloped areas could be our work emphasis. Although this study specially included cancer drug trials, the results could also provide reference for trials in all other fields....
RESEARCH | Published: 13 Oct 2020

Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

Pages: 45-51 PDF(1210KB) Views：3577Downloads：2
Whole-exome sequencing reveals genetic underpinnings of tongue carcinoma in Chinese population

Shuhang Wang, Ning Jiang .. Ning Li

Oral tongue squamous cell carcinoma (OTSCC) is a common malignancy, of which the incidence has increased in China in the last decade. Surprisingly, while multiple studies have revealed the mutational features of OTSCC in Western populations, limited data was shown in Asian patients. Herein, we utilized whole-exome sequencing to profile the genetic alterations in 13 Chinese OTSCC and compared them ...
RESEARCH | Published: 19 Oct 2020

Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

Pages: 52-60 PDF(1920KB) Views：3473Downloads：2
Implication of expression of MMR proteins and clinicopathological characteristics in gastric cancer

Renu Verma, Puja Sakhuja ... Prakash Chand Sharma

Microsatellite instability (MSI), referred to as variations at microsatellite loci, at mismatch repair (MMR) genes leads to the formation of an aberrant MMR system that fails to rectify errors occurring during DNA replication. MMR deficiency can be assessed by immunohistochemical analysis of the expression of mismatch repair proteins in the target tissues. Our results implicate the role of mismat...
RESEARCH | Published: 30 Dec 2020

Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

Pages: 61-67 PDF(4210KB) Views：1603Downloads：4
Navigating in the labyrinth of thrombotic and bleeding risks in patients with malignancies – how to make the most reasonable choices for personalized anticoagulation?

Katarzyna (Kate) Rygiel

Venous thromboembolism (VTE) frequently occurs among patients with malignancies and poses an important cause of morbidity and mortality in this population. Therefore, effective and safe thromboprophylaxis for oncology patients at the increased risk of VTE is of utmost importance. Commonly used anticancer treatments, including hormonal therapy (HT), chemotherapy (CHT), targeted therapy (TT), immune...
REVIEW | Published: 31 Dec 2020

Asia-Pacific Journal of Oncology, Articles, Volume 1 (2020)

Pages: 68-76 PDF(1280KB) Views：1220Downloads：3

Articles , Volume 1 (2020)

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